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(UPDATE) TOKYO — In the initial clinical trial of this nature, researchers from Japan reported that a stem cell therapy enhanced the mobility of two out of four participants who had suffered injuries to their spinal cords.

At present, there is no reliable cure for paralysis resulting from severe spinal cord injuries. In Japan, these conditions impact over 150,000 individuals, with an additional 5,000 new cases reported annually.

Scientists from Tokyo’s Keio University are carrying out their research utilizing induced pluripotent stem cells (iPS), which are generated by reverting mature, already differentiated, cells back into an immature state.

They can subsequently be induced to develop into various cell types, with the Keio researchers utilizing iPS-derived neural stem cells.

On Friday, the university stated that following an operation involving the insertion of over 2 million iPS-generated cells into their spinal cords, the motor skills scores for two patients showed improvement.

The institution stated that over a year of observation, no significant negative effects were noted in all four instances.

The primary objective of the research was to examine the safety of administering the cells through injection.

The public broadcaster NHK stated that out of the two individuals involved, one was an older gentleman who sustained his injuries due to an incident.

He can now stand unsupported and has begun practicing his steps, according to NHK.

According to NHK, Hideyuki Okano, a Keio University professor leading the research, stated that they achieved outcomes from the globe’s inaugural spinal cord therapy using iPS cells.

Okano mentioned that the group aimed to progress to a clinical trial, which would be a crucial next stage before making the treatment available for patients.

In 2019, the educational institution obtained governmental permission for their preliminary research, and they conducted the inaugural surgery in 2022.

The details of the patients are kept private, however, the team is concentrating on individuals who sustained injuries between 14 to 28 days prior to the procedure.

The quantity of cells transplanted was established following safety trials in creatures.


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